| Laboratory of Human Genome Research, Ministry of Public Health, P.R. China & Shanghai Key Laboratory of Human Genome Research | Unit for approval: Ministry of Public Health, Shanghai Science and Technology Commission Date of approval: October 1994, September 1993 Laboratory director: Chen Zhu Makeup of the laboratory: Research Department of Diagnosis and Pathogenesis of Hematopathy, Basic Research Department of Therapeutics of Hematopathy, Medical Genomics Research Department, Molecular Genetics Research Section, Vascular Biology Research Section, Research Section of Endocrine and Metabolic Diseases
Research directions: 1£® Establishing the comprehensive technical system of structural and functional genome 1) New technique of fast screening of SNPs 2) New technique of batch screening of gene expression maps and protein expression maps 3) New technique of fairly large-scale research of interaction of biologic macromolecules (protein-protein, protein-nucleic acid) and initial screening of gene function at cellular level 4) New technique of research of gene function at an overall level 2£® Research of genomics and diagnosis and therapy of human diseases 1) Research of normal hemopoiesis and genes related to neuroendocrine system 2) New-type diagnosis of human diseases based on genome information 3) New breakthrough of realizing the therapy of tumor differentiation, apoptosis and induction Disease models: leukemia and solid tumor, endocrine diseases angiocardiopathy, genetic diseases 3£® Research of basic theory of traditional Chinese medicine and mechanism of effect of active principles
Main large-scale instruments and apparatuses: 1. DNA sequencer-373 2. Computer workstation 3. Stream-pattern cell analyzer 4. Chromosome analyzer 5. Multicolor fluorescent in situ cross breeding apparatus 6. Phosphorus screen imaging system 7. Quantitative PCR apparatus
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